https://melnicklab.org/blog-journals daily 0.75 2022-12-08 https://melnicklab.org/blog-journals/blog-post-title-two-llfwg monthly 0.5 2022-12-08 https://melnicklab.org/blog-journals/blog-post-title-one-8amdh monthly 0.5 2022-12-08 https://melnicklab.org/blog-journals/blog-post-title-three-dprse monthly 0.5 2022-12-08 https://melnicklab.org/publications-1 daily 0.75 2024-03-08 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-fz4p6-844b6 monthly 0.5 2024-03-08 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/9010cd9c-d579-4c54-b7e7-20446befde67/arid1a.jpg Publications - ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. - Make it stand out Barisic, D., Chin, C. R., Meydan, C., Teater, M., Tsialta, I., Mlynarczyk, C., Chadburn, A., Wang, X., Sarkozy, M., Xia, M., Carson, S. E., Raggiri, S., Debek, S., Pelzer, B., Durmaz, C., Deng, Q., Lakra, P., Rivas, M., Steidl, C., Scott, D. W., Weng, A. P., Mason, C. E., Green, M. R., Melnick, A. (2024). ARID1A orchestrates SWI/SNF-mediated sequential binding of transcriptional factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. Cancer Cell. https://doi.org/10.1016/j.ccell.2024.02.010 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-fz4p6 monthly 0.5 2024-03-08 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/65703f8f-0bff-4c79-ae83-c966a014db3c/btg1.jpg Publications - BTG1 mutation yields supercompetitive B cells primed for malignant transformation - Make it stand out Mlynarczyk, C., Teater, M., Pae, J., Chin, C. R., Wang, L., Arulraj, T., Barisic, D., Papin, A., Hoehn, K. B., Kots, E., Ersching, J., Bandyopadhyay, A., Barin, E., Poh, H. X., Evans, C. M., Chadburn, A., Chen, Z., Shen, H., Isles, H. M., Pelzer, B., … Melnick, A. (2023). BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.), 379(6629), eabj7412. https://doi.org/10.1126/science.abj7412 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-rjt5r monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/f5cee6bd-4015-4de2-bfa1-df28d99e0a8f/m_candisc_13_1_cover.png Publications - An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas - Make it stand out Venturutti, L., Rivas, M. A., Pelzer, B. W., Flümann, R., Hansen, J., Karagiannidis, I., Xia, M., McNally, D. R., Isshiki, Y., Lytle, A., Teater, M., Chin, C. R., Meydan, C., Knittel, G., Ricker, E., Mason, C. E., Ye, X., Pan-Hammarström, Q., Steidl, C., Scott, D. W., … Melnick, A. M. (2023). An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas. Cancer discovery, 13(1), 216–243. https://doi.org/10.1158/2159-8290.CD-22-0561 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-yj9lm monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/97f95b80-bf9e-4f11-9d7b-92442d5c54ae/m_candisc_12_8_cover.png Publications - BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL - Make it stand out Xia, M., David, L., Teater, M., Gutierrez, J., Wang, X., Meydan, C., Lytle, A., Slack, G. W., Scott, D. W., Morin, R. D., Onder, O., Elenitoba-Johnson, K. S. J., Zamponi, N., Cerchietti, L., Lu, T., Philippar, U., Fontan, L., Wu, H., & Melnick, A. M. (2022). BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer discovery, 12(8), 1922–1941. https://doi.org/10.1158/2159-8290.CD-21-1566 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-ex78t monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/5f1bf6b6-a500-41dc-8eca-9257f27008e2/m_candisc_12_7_cover.png Publications - SETD2 Haploinsufficiency Enhances Germinal Center–Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis - Make it stand out Leung, W., Teater, M., Durmaz, C., Meydan, C., Chivu, A. G., Chadburn, A., Rice, E. J., Muley, A., Camarillo, J. M., Arivalagan, J., Li, Z., Flowers, C. R., Kelleher, N. L., Danko, C. G., Imielinski, M., Dave, S. S., Armstrong, S. A., Mason, C. E., & Melnick, A. M. (2022). SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. Cancer discovery, 12(7), 1782–1803. https://doi.org/10.1158/2159-8290.CD-21-1514 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-n8pyr monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/1ac19bee-7bf2-4731-8379-94ad7650deff/m_bloodcandisc_3_1_cover.png Publications - Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival - Make it stand out Li, M., Teater, M. R., Hong, J. Y., Park, N. R., Duy, C., Shen, H., Wang, L., Chen, Z., Cerchietti, L., Davidson, S. M., Lin, H., & Melnick, A. M. (2022). Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival. Blood cancer discovery, 3(1), 50–65. https://doi.org/10.1158/2643-3230.BCD-20-0183 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-akjcd monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/68223692-be86-43fa-a418-d6e5488c6582/oct2.jpeg Publications - OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity - Make it stand out Doane, A. S., Chu, C. S., Di Giammartino, D. C., Rivas, M. A., Hellmuth, J. C., Jiang, Y., Yusufova, N., Alonso, A., Roeder, R. G., Apostolou, E., Melnick, A. M., & Elemento, O. (2021). OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity. Nature immunology, 22(10), 1327–1340. https://doi.org/10.1038/s41590-021-01025-w https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-7sjcn monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/271e19a6-43fa-4061-b54b-a165204deebb/cohesin.jpeg Publications - Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes - Make it stand out Rivas, M. A., Durmaz, C., Kloetgen, A., Chin, C. R., Chen, Z., Bhinder, B., Koren, A., Viny, A. D., Scharer, C. D., Boss, J. M., Elemento, O., Mason, C. E., & Melnick, A. M. (2021). Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes. Frontiers in immunology, 12, 688493. https://doi.org/10.3389/fimmu.2021.688493 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/080e20d1-6d07-4efb-9366-02f57c5ae173/chemotherapy_cihan.jpeg Publications - Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence - Make it stand out Duy, C., Li, M., Teater, M., Meydan, C., Garrett-Bakelman, F. E., Lee, T. C., Chin, C. R., Durmaz, C., Kawabata, K. C., Dhimolea, E., Mitsiades, C. S., Doehner, H., D'Andrea, R. J., Becker, M. W., Paietta, E. M., Mason, C. E., Carroll, M., & Melnick, A. M. (2021). Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence. Cancer discovery, 11(6), 1542–1561. https://doi.org/10.1158/2159-8290.CD-20-1375 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-3bn89 monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/010b502c-06bd-4b02-8f97-f89c9c7519b6/smc3_martin_nature_immun.jpg Publications - Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation - Make it stand out Rivas, M. A., Meydan, C., Chin, C. R., Challman, M. F., Kim, D., Bhinder, B., Kloetgen, A., Viny, A. D., Teater, M. R., McNally, D. R., Doane, A. S., Béguelin, W., Fernández, M. T. C., Shen, H., Wang, X., Levine, R. L., Chen, Z., Tsirigos, A., Elemento, O., Mason, C. E., … Melnick, A. M. (2021). Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation. Nature immunology, 22(2), 240–253. https://doi.org/10.1038/s41590-020-00827-8 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-3bn89-cy6y8 monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/1c976b85-ffbd-42f4-85aa-e1963ffacd31/h1_nevin.jpg Publications - Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture - Make it stand out Yusufova, N., Kloetgen, A., Teater, M., Osunsade, A., Camarillo, J. M., Chin, C. R., Doane, A. S., Venters, B. J., Portillo-Ledesma, S., Conway, J., Phillip, J. M., Elemento, O., Scott, D. W., Béguelin, W., Licht, J. D., Kelleher, N. L., Staudt, L. M., Skoultchi, A. I., Keogh, M. C., Apostolou, E., … Melnick, A. M. (2021). Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature, 589(7841), 299–305. https://doi.org/10.1038/s41586-020-3017-y https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-zxfwy monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/4ade526e-47a6-4220-bd45-131e82ef4d91/chu_cell.jpeg Publications - Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage - Make it stand out Chu, C. S., Hellmuth, J. C., Singh, R., Ying, H. Y., Skrabanek, L., Teater, M. R., Doane, A. S., Elemento, O., Melnick, A. M., & Roeder, R. G. (2020). Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage. Molecular cell, 80(5), 845–861.e10. https://doi.org/10.1016/j.molcel.2020.10.036 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/689c9f89-6edf-4f39-a63c-c34334443d4e/m_candisc_10_12_cover.png Publications - Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML - Make it stand out Li, S., Chen, X., Wang, J., Meydan, C., Glass, J. L., Shih, A. H., Delwel, R., Levine, R. L., Mason, C. E., & Melnick, A. M. (2020). Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML. Cancer discovery, 10(12), 1934–1949. https://doi.org/10.1158/2159-8290.CD-19-0897 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-6rear monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/044f022e-0fa3-4597-ada8-b472091aa2ff/tbl1xr1.jpg Publications - TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate - Make it stand out Venturutti, L., Teater, M., Zhai, A., Chadburn, A., Babiker, L., Kim, D., Béguelin, W., Lee, T. C., Kim, Y., Chin, C. R., Yewdell, W. T., Raught, B., Phillip, J. M., Jiang, Y., Staudt, L. M., Green, M. R., Chaudhuri, J., Elemento, O., Farinha, P., Weng, A. P., … Melnick, A. M. (2020). TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell, 182(2), 297–316.e27. https://doi.org/10.1016/j.cell.2020.05.049 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-6rear-lp92c monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/2abcde3c-02ac-49d4-bbe9-1960274d1117/ezh2.jpg Publications - Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response - Make it stand out Béguelin, W., Teater, M., Meydan, C., Hoehn, K. B., Phillip, J. M., Soshnev, A. A., Venturutti, L., Rivas, M. A., Calvo-Fernández, M. T., Gutierrez, J., Camarillo, J. M., Takata, K., Tarte, K., Kelleher, N. L., Steidl, C., Mason, C. E., Elemento, O., Allis, C. D., Kleinstein, S. H., & Melnick, A. M. (2020). Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response. Cancer cell, 37(5), 655–673.e11. https://doi.org/10.1016/j.ccell.2020.04.004 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-sbtba monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/2b0702eb-cccc-47ef-a724-114532924a6b/sirt3.jpg Publications - Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis - Make it stand out Li, M., Chiang, Y. L., Lyssiotis, C. A., Teater, M. R., Hong, J. Y., Shen, H., Wang, L., Hu, J., Jing, H., Chen, Z., Jain, N., Duy, C., Mistry, S. J., Cerchietti, L., Cross, J. R., Cantley, L. C., Green, M. R., Lin, H., & Melnick, A. M. (2019). Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer cell, 35(6), 916–931.e9. https://doi.org/10.1016/j.ccell.2019.05.002 https://melnicklab.org/publications-1/blog-post-title-one-rbrkd-ena8g-tzrtp monthly 0.5 2023-11-10 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/b2a3e107-6987-4970-8325-eea0e868ca89/m_candisc_9_7_cover.png Publications - Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML - Make it stand out Duy, C., Teater, M., Garrett-Bakelman, F. E., Lee, T. C., Meydan, C., Glass, J. L., Li, M., Hellmuth, J. C., Mohammad, H. P., Smitheman, K. N., Shih, A. H., Abdel-Wahab, O., Tallman, M. S., Guzman, M. L., Muench, D., Grimes, H. L., Roboz, G. J., Kruger, R. G., Creasy, C. L., Paietta, E. M., … Melnick, A. M. (2019). Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML. Cancer discovery, 9(7), 872–889. https://doi.org/10.1158/2159-8290.CD-19-0106 https://melnicklab.org/publications-1/category/2021 monthly 0.5 https://melnicklab.org/publications-1/category/2020 monthly 0.5 https://melnicklab.org/publications-1/tag/Arthur+I+Skoultchi monthly 0.5 https://melnicklab.org/publications-1/tag/Jing+Hu monthly 0.5 https://melnicklab.org/publications-1/tag/Xiaofei+Ye monthly 0.5 https://melnicklab.org/publications-1/tag/Ross+L+Levine monthly 0.5 https://melnicklab.org/publications-1/tag/Jaison+Arivalagan monthly 0.5 https://melnicklab.org/publications-1/tag/Gabriel+D+Victora monthly 0.5 https://melnicklab.org/publications-1/tag/Aaron+D+Viny monthly 0.5 https://melnicklab.org/publications-1/tag/C+David+Allis monthly 0.5 https://melnicklab.org/publications-1/tag/Min+Xia monthly 0.5 https://melnicklab.org/publications-1/tag/Rajat+Singh monthly 0.5 https://melnicklab.org/publications-1/tag/Ekaterina+Kots monthly 0.5 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https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-xwwc7-sesje monthly 0.5 2024-03-08 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/96f025ee-87df-4e3f-89c6-5894bdca1dbe/darko.jpg News - Congratulations to Darko Barisic on publishing his paper on how mutations in ARID1A orchestrates SWI/SNF-mediated changes in chromatin dynamics and immune cell-fate to drive lymphoma! Congratulations to Darko Barisic on publishing his paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma. Special shout out to Cem Meydan and Chris Chin for their help in this study. Check it out here at Cancer Cell! https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-xwwc7 monthly 0.5 2024-03-08 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/5a833435-1928-4d37-82f6-af7710b8f649/Coco_2.jpg News - Congratulations to Coraline Mlynarczyk on accepting a tenure-track Assistant Professor position at Yale School of Medicine! Congratulations to Coraline Mlynarczyk on accepting a tenure-track Assistant Professor position at Yale Cancer Center and Yale School of Medicine, starting July 1st, 2024. Prospective trainees should definitely reach out!! https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx monthly 0.5 2024-02-15 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/1706243266595-VNHH6RLUHM4AVR74FBAI/min.jpg News - Congratulations to Min Xia on receiving the Lymphoma Research Mentoring Program (LSRMP) Grant! Congratulations to Min Xia on being awarded the Lymphoma Scientific Research Mentoring Program (LSRMP) grant from the Lymphoma Research Foundation (LRF) and becoming a LRF Scholar! The LSRMP offers mentoring and education to hematology/oncology fellows, postdoctoral fellows and junior faculty dedicated to clinical, laboratory, and translational research in the field of lymphoma and CLL. The award intends to enhance the ability of LRF Scholars to successfully design and administer research studies, successfully apply for future grant funding, and collaborate with other researchers in the field. https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-78z3f monthly 0.5 2024-02-15 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/1707980879005-GWPOC8YIQL56OHKOWZ1Z/catie.jpg News - Congratulations to Caitie Gribbin on receiving the Lymphoma Research Mentoring Program (LSRMP) Grant! Congratulations to Caitie Gribbin on being awarded the Lymphoma Scientific Research Mentoring Program (LSRMP) grant from the Lymphoma Research Foundation (LRF) and becoming a LRF Scholar! The LSRMP offers mentoring and education to hematology/oncology fellows, postdoctoral fellows and junior faculty dedicated to clinical, laboratory, and translational research in the field of lymphoma and CLL. The award intends to enhance the ability of LRF Scholars to successfully design and administer research studies, successfully apply for future grant funding, and collaborate with other researchers in the field. https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-78z3f-cmnj7 monthly 0.5 2024-02-15 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/1707980879005-GWPOC8YIQL56OHKOWZ1Z/catie.jpg News - Congratulations to Caitie Gribbin on receiving the Burroughs Welcome Fund for Physician Scientists!! Congratulations to Caitie Gribbin on receiving the Burroughs Welcome Fund for Physician Scientists, Weill Cornell Chapter! This program seeks to equip academic clinical departments to train MD-only trainees and physicians of all clinical disciplines for full time careers in laboratory investigation. To achieve this goal, it will specifically furnish trainees (ranging from late stage medical students to residents and post-graduate trainees) with: (i) longitudinally structured, multidisciplinary career development plans that integrate individualized scientific training into clinical training from the time of matriculation. These plans will be explicitly tied to the professional finish line of faculty independence; (ii) financial support for extended full time research training; (iii) help managing the competing demands of work-life balance related to primary caregiver responsibilities; and (iv) membership in a Multi-institutional Consortium dedicated to the Advancement of Physician Scientists (MCAPS) whose explicit goal is to jumpstart professional networking and thereby facilitate longitudinal career stage transitions. This program emphasizes three core concepts that address key barriers identified by the NIH Physician–Scientist Working Group: Start early, Stay focused, and Stay connected. https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-j5kpm monthly 0.5 2024-01-26 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/6936ca4b-0234-4dbe-99ba-b7b8a1e67eaf/yusuke.jpg News - Congratulations to Yusuke Isshiki on receiving the Leukemia & Lymphoma Society (LLS) Special Fellow Award! Congratulations to Yusuke Isshiki on being awarded the the Leukemia & Lymphoma Society (LLS) Special Fellow Award! The Special Fellow Award supports top-performing postdocs and instructors who have clearly demonstrated success in their current postdoctoral/instructor position and who need 2-3 years of training to be competitive for an independent position. Yusuke’s major research interest is to improve the outcome of poor prognosis B cell lymphooma by mechnaism-based epigenetic targeting therapy, and his future professional goal is to start his laboratory as a physician-scientist and perform innovative translational research based on solid mechanistic biology. https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-xmefz monthly 0.5 2024-02-15 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/06a42364-271c-4650-94ff-994bf7055efa/catie.jpg News - Congratulations to Caitie Gribbin on being awarded the American Society of Clinical Oncology Young Investigator Award! Congratulations to Caitie Gribbin on being awarded the 2023 American Society of Clinical Oncology Young Investigator Award for her follicular lymphoma research. The Young Investigator Award provides funding to promising investigators to encourage and promote quality research in clinical oncology. Each year, the American Society of Clinical Oncology (ASCO) Conquer Cancer Foundation selects a group of young physicians working on exciting research projects to receive this award. Under the mentorships of Drs. Ari Melnick and Wendy Beguelin, Caitie’s research focuses on elucidating the role of follicular dendritic cells in EZH2-mutated follicular lymphoma progression and transformation. https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-6j6cs monthly 0.5 2024-01-26 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/aa6b6f5e-ec3d-4dc3-85c7-eb91571fc37c/sanket.jpg News - Congratulations to Sanket Shah on receiving the Lymphoma Research Foundation (LRF) Postdoctoral Fellowship Grant! Congratulations to Sanket Shah on being awarded the the Lymphoma Research Foundation (LRF), Bruce D. Cheson Postdoctoral Fellowship grant! LRF maintains a strong commitment to supporting early career investigators, ensuring they can build a successful career in the field of lymphoma research. Sanket’s research focuses on Precision Epigenetic Therapy for B-cell lymphomas. Diffuse large B-cell lymphomas (DLBCL) are a heterogeneous group of lymphomas associated with poor outcomes and high rates of mortality. Mutations in genes that encode proteins responsible for regulation of gene expression, known as epigenetic regulators, are common in these types of lymphomas. One such protein is SETD2, the mutation of which leads to tumor formation in DLBCL. Dr. Shah’s research aims to understand if and how SETD2 inhibitors can be used in DLBCL. Importantly, these types of mutations are most common in people of African ancestry. “We believe that SETD2 inhibition will induce genomic catastrophe, and [this] work may yield the first ever health-disparities precision therapy for cancer and address a critical unmet need in the lymphoma field,” he says. Dr. Shah earned his PhD from Tata Cancer Hospital in Mumbai, India. He is currently serving as a postdoctoral fellow at Weill Cornell Medicine in New York, NY, where he is able to combine his research interests in epigenetics, oncology, and immunology. He hopes to use these experiences to jump-start a career studying the immunoepigenetics of DLBCL and the potential to leverage this information for treatment. “Lymphomas are clinically heterogenous tumors,” he says. “However, considering the enrichment in the mutation spectrum of epigenetic regulators, precision epigenetic therapy gives me hope for the future.” https://melnicklab.org/news/blog-post-title-one-76yyy-te5r3 monthly 0.5 2024-01-26 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/347996e3-bac3-4f87-b670-493aa1725e8b/ceyda.jpg News - Congratulations to Ceyda Durmaz on receiving the NCI F31 Award! Congratulations to Ceyda Durmaz on being awarded the NIH NCI Ruth L. Kirschstein NRSA for Individual Predoctoral Fellows (F31) Award! This grant supports promising doctoral candidates who will perform dissertation research and training for a PhD degree in a scientific health-related field relevant to the mission of the NCI during the tenure of the award. Ceyda’s project focuses on how 3D chromatin chromunities, interactive networks of enhancers, drive transcriptional reprogramming in humoral immunity and B-cell lymphomas. https://melnicklab.org/news/blog-post-title-one-76yyy-94gsx-j5kpm-3eec7 monthly 0.5 2024-01-26 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/6936ca4b-0234-4dbe-99ba-b7b8a1e67eaf/yusuke.jpg News - Congratulations to Yusuke Isshiki on receiving Overseas Research Fellowship from the Japan Society for the Promotion of Science. Congratulations to Yusuke Isshiki on being awarded the Overseas Research Fellowship from the Japan Society for the Promotion of Science. This fellowship aims to foster highly capable researchers with wide international perspectives and gives excellent young Japanese researchers an opportunity to carry out long-term research at an overseas university or research institution. https://melnicklab.org/news/blog-post-title-one-76yyy monthly 0.5 2024-01-26 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/c38287d1-1df2-4a9a-a0f6-b5e24cfbf8b5/darko.jpeg News - Congratulations to Darko Barisic on hisNIH K99/R00 Pathway to Independence Award Congratulations to Darko Barisic on being awarded the NIH K99/R00 Pathway to Independence Award! This prestigious award will help provide NIH research support for his transition into an independent research career. https://melnicklab.org/news/ma9or0b90upb5kyxe3hvq4b470ynk9 monthly 0.5 2023-09-14 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/ed9d2bf1-2c9d-420b-8a93-3c864c43f5b1/sirt3.jpeg News - Scientists Find Core Vulnerability In Aggressive Lymphomas - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://melnicklab.org/news/blog-post-title-two-rjs5r monthly 0.5 2023-09-14 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/bcf89953-3b76-4c6d-a870-4e896380a414/nasa.jpg News - Nasa Astronaut Twins Study - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://melnicklab.org/news/blog-post-title-three-ekpw9 monthly 0.5 2023-09-14 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/9891ba67-f062-4e04-ac5b-fa4c96744a2f/hsf1.jpeg News - Blocking Ancient Stress Gene May Aid Cancer Treatment - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://melnicklab.org/news/blog-post-title-four-th7y2 monthly 0.5 2023-09-14 https://melnicklab.org/news/etmeh4qp476ltue3bkko1cxvsxgu7b monthly 0.5 2023-09-14 https://melnicklab.org/news/bureo49ag43dn27rm50c2fsvei3yeh monthly 0.5 2023-09-14 https://melnicklab.org/news/u467ux9i7hormvr5vgwnii0jxw6nlo monthly 0.5 2023-09-14 https://images.squarespace-cdn.com/content/v1/638fea57956f912c0ac1ad97/9013c2e7-32b2-4f67-9b76-6140a8e97a4a/ruanmelnickshanghai.jpeg News - Global Collaboration: Lymphoma Researchers Attend Workshop at Shanghai Institute of Hematology - Dr. Melnick in Shanghai. https://cornell-lymphoma.com/tag/ari-melnick-md/ https://melnicklab.org/news/tag/ASCO monthly 0.5 https://melnicklab.org/news/tag/LRF 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